ICSI stands for intra-cytoplasmic sperm injection. This is a procedure which is reserved for men with poor quality sperm, or in whom sperm has had to be collected directly from the testicle, using a local or general anaesthetic technique.
On average, about 70% of injected eggs are successfully fertilized by the ICSI process. This has been successful in overcoming previously hopeless situations for couples with male sub-fertility. It can also be used in situations where there has been unexplained failure of fertilization of apparently normal eggs by normal looking sperm.
The process is initially the same as for an IVF cycle. When the eggs are collected, the scientist brings them to the laboratory. There, he or she isolates a single sperm and injects it directly into the egg.
Fertilization is checked the following day and one or two good embryos are transferred to the uterus on day 2 or day 3 after the egg pick up procedure. Excess embryos can be frozen. Although ICSI seems a very invasive procedure, there have so far been no reports of any problems with the motor or intellectual development of children born after IVF and ICSI.